Designing Drugs with AI: Rhizome OS-1 Expands Chemical Space
![Rhizome OS-1 employs an iterative design loop-cycling through structural analysis, molecular generation via the r1 engine, filtering, and evaluation-to discover novel compounds, leveraging [latex]1,000-2,000[/latex] molecules per target in a convergence library and scoring affinity with Boltz-2 against calibrated benchmarks, all orchestrated to optimize seed selection and refine generation strategies.](https://arxiv.org/html/2604.07512v1/assets/rhizome_architecture.png)
A new AI-powered platform is automating the design of novel small molecules, offering a promising approach to accelerate drug discovery and enhance chemical diversity.
![Rhizome OS-1 employs an iterative design loop-cycling through structural analysis, molecular generation via the r1 engine, filtering, and evaluation-to discover novel compounds, leveraging [latex]1,000-2,000[/latex] molecules per target in a convergence library and scoring affinity with Boltz-2 against calibrated benchmarks, all orchestrated to optimize seed selection and refine generation strategies.](https://arxiv.org/html/2604.07512v1/assets/rhizome_architecture.png)
A new AI-powered platform is automating the design of novel small molecules, offering a promising approach to accelerate drug discovery and enhance chemical diversity.

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